Research @ UPIKE

The clinical research priority areas include osteopathic manipulative treatment, osteopathic patient care, clinical case research, community health research and research for primary care in underdeveloped areas.

The research program at KYCOM strives to serve as a continuation of the mission of the college and provide solutions for problems that are prevalent in the rural areas of Appalachia.

The combination of research, scholarship, and teaching are all valuable aspects needed in the training of osteopathic physicians. Student fellowships for research are available to KYCOM students in good academic standing.

In addition to providing valuable information to the medical community, students who participate in research, gain valuable information about experimental designs, data collection, and analysis as well as important techniques for biomedical research.

The research program at KYCOM aims to advance biomedical knowledge, give students opportunity to grow beyond the curriculum framework, and produce future physicians who will continue improving health in Appalachian communities.

The biomedical science research priority areas include cancer prevention and treatment, cardiovascular physiology, aging of the immune system in the context of thymic structure and function, mammalian macroevolution, diabetes research, black lung and medical education research.

Kartick Pramanik, Ph.D.; M. Pharm.

The central goal of Dr. Pramanik’s research is to discover natural, or biologic compounds in the prevention of pancreatic cancer progression and chemo-resistance.  Currently, his laboratory is actively engaged to understand the underlying mechanism of induction of senescence and activation of chemo-sensitization by natural agents: (A) Senescence is the proliferative arrest of cells in the cell cycle. Cells remain metabolically and synthetically active but are not able to proliferate. Therefore, senescence has become a favorable tumor suppressor therapy in cancer. Like many other cancers, pancreatic cancer often involves the inactivation of, or a mutation p53 tumor suppressor gene. Experimental evidence has shown that p53 loss allows cells to escape cell cycle proliferative arrest and activation of p53 induces senescence. My laboratory is actively involved to investigate the underlying mechanism of activation of p53 by natural agents in the induction of senescence. (B) The major obstacle to successful treatment in patients with pancreatic cancer is due to multi-drug resistance (MDR) which is a decreased effectiveness of an anticancer drug. Extensive studies reported that both p53 and multi-drug transporters play important roles in chemoresistance. The laboratory is also involved to understand the fundamental mechanism of natural agents in the induction of P53 leading to chemo-sensitization of gemcitabine in pancreatic cancer cells.

Publications:

Ji, Z.-L., Yao, L., Pramanik, K. C., Cai, Z. J., eds. Artificial Intelligence for Translational Pharmacology. Lausanne: Frontiers Media SA. Frontier in Pharmacology, doi: 10.3389/978-2-88963-888-8, 2020

Vijay P Kale, Hasan Habib, Robert Chistren, Milan Patel, Kartick C. Pramanik, Subash Jonnalagadda, Kishore Challagundla, Manoj K Pandey*. Old drugs new bold purpose: Assessing drug repurposing in hematological and childhood malignancies. Semen Cancer Biol. 2020 Mar 6. pii: S1044-579X(20)30063-8. doi: 10.1016/j.semcancer.2020.03.005.

Monish Ram Makena, Himavanth Gatla, Dattesh Verlekar, Sahithi Sukhavasi, Manoj K. Pandey, and Kartick C. Pramanik*. Wnt/β-catenin Signaling: The culprit in Pancreatic Carcinogenesis and Therapeutic Resistance. Int. J. Mol. Sci. 20, 4242, 2019

Kartick C. Pramanik, Monish Ram Makena, Kuntal Bhowmick and Manoj K. Pandey, Advancement of NF-κB Signaling Pathway: A Novel Target in Pancreatic Cancer. Int. J. Mol. Sci. Nov 19, 3890; doi:10.3390/ijms19123890. 2018

Wu W, Karelia D, Pramanik K, Amin SG, Sharma AK, Jiang C, Lu J, Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. Mol Carcinog. Aug;57(8):1055-1066, 2018

Yong Zhang, Yinhui Dong, Michael W. Melkus, Shutao Yin, Su-Ni Tang, Peixin Jiang, Kartick Pramanik, Wei Wu, Sangyub Kim, Min Ye, Hongbo Hu, Junxuan Lu and Cheng Jiang. Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin Mol Cancer Ther. Nov;17(11):2341-2352. doi: 10.1158/1535-7163.MCT-17-1296. 2018

Malgorzata Simm, Ph.D., MSc

Dr. Simm’s research project is highly exploratory and at its initiation stage. Simm is testing the hypothesis that the residual function of thymus persists in humans until the end of life and plays a role in optimizing human immune function. This hypothesis is supported by (i) studies in animal models, (ii) sporadic reports of finding functional thymic activity in postmortem samples from persons over 50 years of age and, (iii) by the growing body of evidence showing the presence of naïve “virgin” T cells in the periphery of persons, who by current medical definitions should not have a functional thymus. There is a noticeable void in the knowledge about the function of the involuted thymus in humans due to the scarceness of human tissues and a lack of standardized methods of testing the postmortem markers of cellular activity such as RNA and protein expression. Simm proposes to fill this gap in knowledge by the initiation of systematic studies on the immunological fitness of thymus in human subjects by assessing the epithelial compartment in thymi harvested from donor bodies used for gross anatomy training at KYCOM. For the appropriate sample representation, we aim to harvest the thymi from persons whose age at the time of death spans from 18 to 80+ years. Utilizing the thymic tissue along with the modern molecular biology and immunocytochemistry techniques, we will focus on research variables that define thymic activity. Simm’s research is highly collaborative and student-oriented, as most of the experimental approach, requires college-level laboratory training. The research team incorporates members of the gross anatomy and immunology departments.

Publications:

This project is in its exploratory stage and did not generate a publication record.  To see Simm’s publications from previous research projects, visit the bibliography at the National Library of Medicine: https://www.ncbi.nlm.nih.gov/myncbi/14KAgwqly6EkP/bibliography/public/

Shumaila Hanif, Ph.D., MSc, MBA

Tuberculosis remains the most serious global infectious disease caused by a single causative organism Mycobacterium tuberculosis. One-fourth of the world’s population has been infected with MTB. Moreover, the incidence of co-infection with HIV, multiple and extensively drug-resistant tuberculosis presents an imminent threat to global health. No new drugs in over thirty years, and no new vaccines in 92 years have been launched. Consequently, the search for new drugs, vaccines and therapies, in general, is an urgent need in global health. Thus, Dr. Hanif’s research interest is in Infectious Diseases specially in developing new diagnostic methods, new drugs and new vaccines for TB. Hanif is also interested in educational research involving students. Currently, Hanif is working on two projects “Osteopathic Medical Student Preferences for PowerPoint Presentation Structure” and “Osteopathic Medical Student’s Preferences for Lecture Delivery.”

Publication

Fadi A, Abdallah L, Hrizat A, Hanif SNM. Toxic shock and shock-like syndrome: The constant threat. Remedy Publications LLC., 2019, 4:1-7.

Ethan Fullwood, Ph.D.

Dr. Fullwood’s research is driven by the desire to better understand mammal macroevolution through the particular lens of dietary ecology. Fullwood’s work has focused largely on primates, and much of it uses digital tools for characterizing functional tooth shape, known as dental topography metrics. Fullwood works on testing the effectiveness of these metrics in capturing dietary ecology in extant primates, examining how they may reflect geographic gradients in food material properties, and then applying these metrics to extinct species. Dental topography metrics are also well suited for capturing potential trends in tooth functional properties as teeth wear. Teeth change shape dramatically as they wear, but some taxa appear to maintain function by sculpting new cutting surfaces. Mammal lineages may evolve to improve their ability to maintain functional wear across macroevolutionary time, with certain dental morphologies, like bilophodonty, representing adaptations that maximize the sculpting of new functional surfaces. Fullwood is beginning a collaborative project studying the effect of longitudinal tooth wear in fossil tapirs to test this hypothesis in the tapiromorph lineage.

Fullwood’s work on functional morphology lays the groundwork for a broader program examining the relationships between rates of morphological evolution and ecological opportunity in mammals. Fullwood has worked with colleagues to combine quantifications of tooth shape and macroevolutionary modeling approaches to investigate the relationship between ecological opportunity and morphological divergence in lemurs. We proposed a new model for lemur evolution in which the exploitation of defended plant resources in expanding forests facilitated ecological diversification. Fullwood has begun a similar study examining rates of evolution, disparity, and climatically mediated ecospace availability in Eocene North American fossil primates, which will explore the responses of this fauna to Paleogene climate fluctuations. This has the potential to enhance our understanding of the evolutionary history of North American primates and explore fundamental evolutionary questions about the response of lineages to ecological opportunity.

Publications

Fulwood EF. Ecometric modelling of tooth shape and precipitation gradients among lemurs on Madagascar. Biological Journal of the Linnean Society 129: 26-40. 2020

Fulwood EF, Boyer DM, Kay RF. Stem members of Platyrrhini are distinct from catarrhines in at least one derived cranial feature. Journal of Human Evolution 100: 16-24, 2016

Guichun Han, M.D., Ph.D.

Research Interest:

Dr. Han’s research focus is in the field of female hormone effects on cardiovascular system. More specifically, Han’s research team studies the role of individual estrogen receptors in coronary blood flow regulation and the interplay of different receptor signaling pathways.  Childbearing age women are protected from coronary heart disease compared to men, owing largely to the female hormones. Studies have confirmed that within six years after menopause, oral estradiol therapy is associated with less progression of subclinical atherosclerosis. In contrast, in women >65 years of age, who have the highest mortality rate, estrogen replacement is associated with even greater risk of coronary heart disease. Han’s research team apply comprehensive research approaches in our investigation. Isometric tension study and microvessle cannulation study are for measuring vascular tension or diameter changes in a chamber that provides a controlled environment for an arterial ring or arteriole under study. Biochemistry and molecular biology approaches are employed for investigating the molecular basis of the functional changes that being observed in the aforementioned functional study. Confocal imaging is to visualize the molecular interactions of the receptor signaling. In their endeavor of making new discovery, they have found intriguing interplay relationships between the classic estrogen receptors ERα/ERβ and the membrane G protein-coupled estrogen receptor 1 (GPER). The crosstalk of between ERα/ERβ and GPER is of the most significant area to explore in the field and the findings will shed light on the current understanding of estrogen effects in cardiovascular system as well as in most organs and tissues where estrogen receptors present. Therefore, their research findings will meet the need of providing molecular basis for new drug targets in the treatment of cardiovascular diseases. Han’s research projects have been funded multiple times by American Heart Association.

Recent Publications

Yang S, Jiang M, Grabowska MM, Li J, Connelly ZM, Zhang J, Hayward SW, Cates JM, Han G, Yu X. Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo. Oncotarget. 2016 Oct 25;7(43):70404-70419. doi: 10.18632/oncotarget.11879.

Yu X, Zhang Q, Zhao Y, Schwarz BJ, Stallone JN, Heaps CL, Han G. Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA. PLoS One. 2017 Mar 9;12(3):e0173085. doi: 10.1371/journal. pone.0173085. eCollection 2017.

Yu X, Zhang Q, Zhao Y, Schwarz BJ, Stallone JN, Heaps CL, Han G. The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries. PLoS One. 2018 Jan 23;13(1):e0191418. doi: 10.1371/journal.pone.0191418. eCollection 2018

Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, Han G, Newell-Fugate A, Tian Y, Majeti R, Liu W4, Xu Y, Wu C, Allred K, Allred C, Sun Y, Guo S. Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1. Diabetes. 2018 Nov 28. pii: db180638. doi: 10.2337/db18-0638 [Epub ahead of print].

One of the aims of the research program at the Kentucky College of Osteopathic Medicine is student-lead.

The program seeks to reinforce KYCOM’s mission statement by encouraging students to participate in research and cultivating an appreciation of lifelong scholarly activity by providing students with the opportunity to learn research techniques and practices. KYCOM students are invited to apply for the summer research program through the KYCOM Student Research Application.

Students selected for the summer research fellowship will receive a stipend. Students work closely with their mentor faculty members throughout the summer.

They can also find their mentor outside the university. Students work with very knowledgeable faculty that will assist them and assure that the research is successful.

Students have the opportunity to present their research work at regional, national and international conferences and during KYCOM Research Day.

Prospective students are encouraged to view the faculty research tab to discover topics of interest.

Students Summer Research:

2021:

• Benjamin Elliot, OMSI: Pharmacological basis for the therapeutic use of traditionally used medicinal plants in gastrointestinal disorders.
• Deea Das, OMSI: Effect of pseudolaric acid B (PAB) on angiogenesis in pancreatic cancer
• Jason Tey, OMSI: Effects of E26 avian erythroblastosis virus transcription factor (ETS)-1 inhibition on hemodialysis arteriovenous fistula (AVF) development in ETS-1 heterozygous knockout rats.
• Jay Patel , OMSI: Significance of Malnutrition of Mother in Fetal Lung Development and Surfactant Deficiency in Preterm Infants.
• Jessica Jurak, OMSI: The Risk of Heart Disease in Patients with Epithelial Ovarian Cancer due to Fluctuations in Estrogen Productions.
• Megan Hennon, OMSI: Relationship of middle ear ossicle morphologies to the conductance of sound at different frequencies.
• Naushair Hussain, OMSI: Pseudolaric acid B (PAB) reverses pancreatic cancer chemoresistance by inhibition of Transforming Growth Factor β activates Kinase 1 (TAK 1) mediated activation of Nuclear Factor kB (NF-kB).
• Morteda Alaamari, OMS I: Characterizing the role of adiponectin in synovitis by immunohistochemical analysis of osteoarthritic tissue.
• Mahnoor Humayun , OMSI: The Long Term Effects of Early Life Stress on Anxiety Related Behavior and Potential Therapy
• Pranuthi Kanneganti, OMSI: Understanding the structure and function of Thymus in Postpubescent Human Subjects
• Rachel Chauvin, OMSI: Investigating the severity of initial COVID-19 effects on lung function on individuals with pre-diagnosed COPD and related disorders in Pike County”
• Richaela Denlinger, OMSI: Understanding the Structure and Function of Thymus in Postpubescent Human Subjects

2020:

• Matthew Talmage, OMS-1: The Incidence of Recurrent Subluxation of Paralytic Hip Subluxation after Reconstructive Bone Surgery in CP: Is Open Reduction Required?
• Lyudmyla Shymkiv, OMS-1: Genomic effects on Drosophila with Dietary induced Diabetic Cardiomyopathy
• Taylor Reardon, OMS-1: Developing anti-inflammatory treatment for neonatal intraventricular hemorrhage
• Raquel Rudy, OMS-1: Genetic effects on Drosophila with diet-induced Diabetic Cardiomyopathy
• Christina Campbell, OMS-1: The effects of Pseudolaric acid B on the epithelial-to-mesenchymal transition in human lung cancer cells.
• Steven M. VanOver, OMS-1: Mock circulation of pediatric heart failure and treatment with mechanical circulatory support.
• David Cline, OMS-1: Pseudolaric acid B (PAB): A novel agent inhibits the pancreatic cancer chemo-resistance.
• Caleb Marsh, OMS-1: Teratogenic Effects of Over-the-Counter Medications on the Developing Embryo
• Preston Rippe, OMS-1: Allograft knee meniscal transplantation in the treatment osteoarthritis of the metatarsophalangeal (mtp) joint of the great toe

2019:

• Ayaz Gen, OMS-1: Selective Targeting of Cells in Zebrafish using Folate Mediated Photodynamic Therapy
• Brandon Hamm, OMS-1: Pseudolaric Acid (PAB) induces senescence with contribution from activation of p53 in pancreatic cancer cells
• Carlee Clemons, OMS-1: The Environmental Protection Agency’s EJSCREEN as a Predictor of Health Outcomes in Hamilton County, Ohio
• Elizabeth Reiner, OMS-1: Contributions of Apoptosis and Necroptosis to Ischemia/Reperfusion and DSS Colitis Induced Cell Death in TIPE0-/- Mice
• Jacob Sifers, OMS-1: Genomic effects on Drosophila with dietary induced Diabetic Cardiomyopathy
• Rathisha Pathmathasan, OMS-1: Addressing Breast Cancer Disparities Through Analysis of the Prevalence and Outcomes of Luminal B Subtype of Breast Cancer Among African American Women Compared to Caucasian Women using Data from Cancer Registries

2018:

• Aaron Overbeck, OMS-1: Identification of Novel Daibetic Cardiomyopathic Genes on the Drosophilia 2nd Chromosome
• Alice Mei, OMS-1: Genomic and Gene Expression Analyses to Discover Genes and Pathways in Human Congenital Diaphragmatic Hernia
• Elexus Carroll, OMS-1: Frequency of medical care as a potential barrier to CRC screening and CRC screening promoters in Pike County: Patients’ perspectives
• Katie Dick, OMS-1: Outpatient Rocephin Usage Effect on Amount of Patient Walk Ins
• Paige Lewis, OMS-1: The Effects of OMT on Pulmonary Massive Fibrosis: A pilot study of a non-invasive therapy to improve respiratory function in Appalachian Coal Miners
• Shaun Hansel, OMS-1: Pseudolaric acid B (PAB) reverse gemcitabine resistance by regulating p53/P-gp axis in pancreatic cancer cells.
• Trina Sircar, OMS-1: Surgical Outcomes of VAD patients with Pre-existing Diabetes Mellitus

2017:

• Rebecca Oliver, OMS-1: The Impact of Appalachian Cultural Values on Palliative Care
• Joshua Raven, OMS-1: The Effects of Thoracic OMT on Pulmonary Massive Fibrosis: A pilot study of a non-invasive therapy to improve respiratory function in Appalachian Coal Miners
• Carson Roberts, OMS-1: In vitro examination of the oncogenic function of Septin proteins in the development or progression of pancreatic cancer
• Ryan Stefancik, OMS-1: Exploring the Role of Oenocytes in Non-alcoholic Fatty Liver Disease in Relation to Diabetes Mellitus using a Drosophila melanogaster Model
• Sofia Pikalova, OMS-1: Evaluation of MPR diagnostic test for diagnosis of ADHD
• Jordan Wong, OMS-1: Investigating the mechanisms of Bisphenol-A – induced leptin secretion in human adipocytes

2016:

• Casey Potts, OMS-1: Investigating fiber type changes of diaphragm muscle in response to hypoxia in mice with and without satellite cells
• Derek De Mann, OMS-1: A Drosophila Model for Understanding the Role of Autophagy in Diabetic Cardiomyopathies
• Dylan Gerlach, OMS-1: Spectroscopic Structural Differences of Tear Film Lipid Layer in Dry Eye
• John Morris, OMS-1: Evaluation of the effectiveness of improvised Tourniquets on a Repressured Human Cadaver Model.
• Maria Cacciotti, OMS-1: Determining precise clinical criteria to reduce delay in recognition and treatment of sepsis among burn patients
• Zachariah Slattery, OMS-1: Septins are oncogenes in pancreatic cancer, whose activity is inhibited by Chmp1A tumor suppressor

Peer-Review Publications:

2021:

• Anna Hargrave , Abu Salim Mustafa, Asma Hanif , Javed H Tunio, Shumaila N M. Hanif. Current Status of HIV-1 Vaccines Vaccines 2021, 9, x. https://doi.org/10.3390/xxxxx
• Siddiqui A; Conditional Removal of Myeloid Cell-Derived Mif through a Cre-loxP System in Mice; The Ohio State University; The Ohio State University. Department of Pathology Undergraduate Research Theses; 2021; http://hdl.handle.net/1811/92556)
• Anderson K, Ryan N, Alkhimovitch A, Siddiqui A, Oghumu S. Inhibition of PI3K Isoform p110γ Increases Both Anti-Tumor and Immunosuppressive Responses to Aggressive Murine Head and Neck Squamous Cell Carcinoma with Low Immunogenicity. Cancers. 13(5). 2021. 953. https://doi.org/10.3390/cancers13050953
• Ryan N, Anderson K, Siddiqui A, Alkhimovitch A, Swingler M, Puthankovilakam D, Satoskar, Oghumu S. MIF inhibits myeloid derived suppressor cell mediated immunosuppression by promoting an inflammatory M1 phenotypic shift. The FASEB Journal, 35, 2021. https://doi.org/10.1096/fasebj.2021.35.S1.00457.
• Anderson K, Ryan N, Alkhimovitch A, Siddiqui A, Oghumu S. Abstract 1486: Inhibition of host PI3K-gamma modulates anti-tumor immunity in poorly immunogenic HNSCC. AACR. 81(13). 2021. 1486. https://doi.org/10.1158/1538-7445.AM2021-1486 ).
• Deena Badger, Rekha Patel, Ashley Lui, Chetna Thawani, Rea Rupani, Gitanjali Vidyarthu, Niketa Patel. Multilevel Regulation of Protein Kinase CδI Alternative Splicing by Lithium Chloride. Molecular and Cellular Biology  American Society for Microbiology.41( 3): 2021, DOI:https://doi.org/10.1128/MCB.00338-20.
• Margaret W. Ndinguri, Carrie A. Black, Anna L. Gosser, Sara Reitz,  Cody Sutphin, Frank R. Fronczek, Lindsay E. Cormier. “Exploring the synthesis and characterization of fac-Re(CO)3L complexes using diethylenetriamine derivative functionalized at the central nitrogen”. Inorganica Chimica Acta 520 (2021) 120291
• Fiani B, Houston R, Siddiqi I, Arshad M, Reardon T, Gilliland B et al. Retro-Odontoid Pseudotumor Formation in the Context of Various Acquired and Congenital Pathologies of the Craniovertebral Junction and Surgical Techniques. Neurospine. 2021 Mar;18(1):67-78. doi: 10.14245/ns.2040402.201. Epub 2020 Nov 18.
• Fiani B, Covarrubias C, Wong A, Doan T, Reardon T, Nikolaidis D, Sarno E. Cerebrolysin for stroke, neurodegeneration, and traumatic brain injury: review of the literature and outcomes. Neurol Sci. 2021 Apr;42(4):1345-1353. doi: 10.1007/s10072-021-05089-2. Epub 2021 Jan 30. PMID: 33515100.
• Fiani B, Reardon T, Ayres B, et al. An Examination of Prospective Uses and Future Directions of Neuralink: The Brain-Machine Interface. Cureus 13(3): e13192. doi:10.7759/cureus.14192.
• Fiani B, Reardon T, Selvage J et al. Awake Spine Surgery: An Eye-Opening Movement. Surg Neurol Int. 2021 May 10;12:222. doi: 10.25259/SNI_153_2021. PMID: 34084649; PMCID: PMC8168649.
• Reardon T, Fiani B, Kosarchuk J, Parisi A, Shlobin N. Management of Lambdoid Craniosynostosis: A Comprehensive and Systematic Review. Pediatr Neurosurg (accepted for publication 8/20/2021).
• Reardon T, Marsh C, Rippe P, et al. Clinical Management of Pediatric Chordomas: A Comprehensive Review. Cureus (submitted for review 8/22/2021).
• Kendarius J. Butler, Angel A. Castro, Tiffany S. Dwyer, Louise M. Hardwick, Melody C. Iacino , Sara G. Manore, Kevin M. Mays, Caylie A. McGlade, Lisa N. Hair, Erin W. Parker, Mikala R. Smith, Morgan T. Turnow, Matthew R. Wilson, Stephanie R. Woodson, William E. Cotham, Michael D. Walla, Jason C. Hurlbert, T. Christian Grattan,  Design, synthesis, and analysis of novel sphingosine kinase-1 inhibitors to improve oral bioavailability.Bioorganic & Medicinal Chemistry Letters  50, 2021.

2020:

• Whitlow E, Mustafa AS, Hanif SNM. An Overview of the Development of New Vaccines for Tuberculosis. Vaccines (Basel). 5; 8(4): E586, 2020. (Doi: 10.3390/vaccines8040586. PMID: 33027958).
• Al Akhrass F, Trackett M, Mikhael E, Akhter S. Hanif SNM. Central Nervous Cryptococcosis and Chronic Hepatitis C: Two Case Reports and Review of the Literature. Clin Surg. 5:2959. 2020.
• Anderson K, Ryan N, Siddiqui A, Pero T, Volpedo G, Cooperstone JL, Oghumu S. Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses. Nutrients. 12(6). 2020. 1701. https://doi.org/10.3390/nu12061701
• Jones, R.N., Erhard S.A., Malham, M.R., Gen, A.Y., Sullivan, K., Olsen K.W., Dale, R.M.,. (2020, March 01). Expression and Functional Characterization of Zebrafish folate receptor 1 During Embryogenesis [Poster presented]. University of Pikeville- KYCOM/ KYCO Research Day /Pikeville , KY, USA.
• Mammen, J. Bott, K. Hans, E.M. Farhangi, K. Adil. The title of the abstract was Unplanned Hospital Encounters Head & Neck Cancer Patients Treated with Radiotherapy. It was presented at the Medical Student Investigation Day at Albany Medical Center in Albany, NY and it was published in The International Journal of Radiation Oncology • Biology • Physics on April 1, 2020. The doi is https://doi.org/10.1016/j.ijrobp.2019.11.075.
• Fiani B, Reardon T, Jenkins R, Covarrubias C, Sekhon M, Soula M, et al. Intramedullary spinal cord cavernous malformations in the pediatric population. Surg Neurol Int 2020;11:275. doi: 10.25259/SNI_494_2020. PMID: 33033637; PMCID: PMC7538982.
• Fiani B, Siddiqi I, Reardon T, Sarhadi K, Newhouse A, Gilliland B, et al. Thoracic Endoscopic Spine Surgery: A Comprehensive Review. Int J Spine Surg Oct 2020, 7109; DOI: 10.14444/7109. Epub 2020 Oct 12. PMID: 33046537; PMCID: PMC7671455.
• Von Mach, T., Rodriguez, K., Mojtabai, R., Spivac, S., Eaton, W., & Cullen, B. (2020). The relationship between social and environmental factors and symptom severity in the seriously mentally ill population. International Journal of Social Psychiatry, 1-6
• Cullen, B., Rodriguez, K., Eaton, W., Mojtabai, R., Von Mach, T., Ybarra., M. (2020). Clinical outcomes from the texting for relapse prevention (T4RP) in schizophrenia and schizoaffective disorder study. Psychiatry Research, 292, 1-5.
• Von Mach, T., MPH MSW, Fawcett, A., MLIS, Hatzis, N., MD, Walker Lowry, K. PhD. “Impact of Partial Hospitalization and Intensive Outpatient Programs for Children and Adolescents: A Systematic Review and Meta-Analysis.” American Public Health Association Annual Meeting; San Francisco, CA; October 2020; Oral Presentation.
• Walker Lowry, K., PhD, Von Mach, T., MPH MSW, Westover, A., MA, Haen, C. LCSW. “Training Pediatric Care Coordinators in Motivational Interviewing.” ABCT Annual Meeting; Philadelphia, PA; November 2020; Poster Presentation.
• Von Mach, T., MPH MSW, Fawcett, A., MLIS, Hatzis, N., MD, Walker Lowry, K. PhD. “Impact of Partial Hospitalization and Intensive Outpatient Programs for Children and Adolescents: A Systematic Review and Meta-analysis.” ABCT Annual Meeting; Philadelphia, PA; November 2020; Poster Presentation.

2019:

• Allen AH, Gullixson AC. Spindle Cell Sarcoma of the Paraspinal Musculature with Late Pulmonary Metastases. American Journal of Case Reports. 2019; 20:828-832. Published 2019 Jun 12. doi:10.12659/AJCR.915602
• Allen AH. Large Undifferentiated Pleomorphic Sarcoma of the Posterior Thigh. American Journal of Case Reports. 2019;20:318-322. Published 2019 Mar 11. doi:10.12659/AJCR.914079.
• Jordan C. Malone, Aravind Thavamani. Physiology, Gastrocolic Reflex (Gastrocolic Response). StatPearls, 2019
• Kinaan Javed; Daniel T. Daly. Neuroanatomy, Lower Motor Neuron Lesion, State pearls, 2019
• Kinaan Javed; Vamsi Reddy; Joe M Das. Neuroanatomy, Posterior Cerebral Arteries, State pearls, Pubmed ID: 30860709
• Kinaan Javed; Joe M Das. Neuroanatomy, Anterior Choroidal Arteries, State pearls, Pubmed ID: 30844216, 2019
• Kinaan Javed; Vamsi Reddy; Forshing Lui. Neuroanatomy, Choroid Plexus, Pubmed ID: 30844183
• Kinaan Javed; Vamsi Reddy; Forshing Lui. Neuroanatomy, Lateral Corticospinal Tract, Pubmed ID: 30521239
• Lauren A. Hocevar; Brian M. Fitzgerald. American Society of Anesthesiologists Staging. PubMedID # 31747192
• Mustafa M. Basree, Neelam Shinde, Christopher Koivisto, Maria Cuitino, Raleigh Kladney, Jianying Zhang, Julie Stephens, Marilly Palletas, Allen Zhang, Hee Kyung Kim, Santiago Beoya, Anthony Trimboli, Daniel Stover, Thomas Ludwig, Ramesh Ganju, Peter Shields, Gustavo Leone, Gina Sizemore, Sarmila Majumder, and Bhuvaneswari Ramaswamy. Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer. Breast Cancer Research 2019, Jul 17;21(1):80.

Poster Presentations:

2021:

• Whitlow E, Mustafa AS, Hanif SNM. An Overview of the Development of New Vaccines for Tuberculosis. 1^st University of Pikeville Research Symposium. Pikeville, KY, USA. Apr 9th, 2021
• Siddiqui A, Ryan N, Anderson K, Volpedo G, Mellen L, Satoskar A PhD, Oghumu S PhD. Cre-lox Mediated Conditional Removal of Myeloid Cell-Derived Mif in a Mouse Model of Oral Cancer. Denman Undergraduate Presentation Forum. Columbus, Ohio, April 7, 2021.
• Ryan N, Anderson K, Siddiqui A, Alkhimovitch A, Swingler M, Puthankovilakam D, Satoskar A, Oghumu S. MIF Inhibits myeloid derived suppressor cell mediated immunosuppression by promoting an inflammatory M1 phenotypic shift. Experimental Biology. Indianapolis, Indiana, April 27-30, 2021.
• Heather McGuirem, Heather McGuire, Malgorzata Simm. Anatomical Evaluation of Human Thymi in Elderly Human subjects- A Pilot Study. 2021 UPIKE Research Symposium
• Jupina, M., Caudill, C., & Sidle, M.W.. (2021, April 09). Medical Student Mental Health During the COVID-19 Pandemic [Poster presented]. University of Pikeville Research Symposium/Pikeville, KY, USA.
• Reardon, T. Pandya C, Vekaria H, Binoy J et. al. Hemoglobin Induces Oxidative Stress and Mitochondrial Dysfunction in Oligodendrocyte Progenitor Cells. Presented by UPike Research Symposium. University of Pikeville, Pikeville, KY. Oral and Poster Presentation, 2021
• Reardon, T. Pursuing & Obtaining Research Opportunities in Medical School. KYCOM Current Issues in Medicine (CIM) course. Kentucky College of Osteopathic Medicine, Pikeville, KY. Oral Presentation. 2021
• Reardon, T. Pandya C, Vekaria H, Binoy J et. al. Hemoglobin Induces Oxidative Stress and Mitochondrial Dysfunction in Oligodendrocyte Progenitor Cells. Presented by. KYCOM Current Issues in Medicine (CIM) course. Kentucky College of Osteopathic Medicine, Pikeville, KY. Oral Presentation.          2021
• Bott, Joseph, Brian Cohen. Analysis of Caveolin-1 Expression and Interaction with Human Follicle Stimulating Hormone Receptor in Lipid Rafts. Steinmetz Research Symposium at Union College in Schenectady, NY , May of 2021.
• Nicole Mitchell, Meg Wright Sidle, Joe Kingery The educational impact of the COVID-19 pandemic on medical students in the United States.Student National Medical Association Region X Conference, 2021
• Nicole Mitchell, Meg Wright Sidle, Joe Kingery The educational impact of the COVID-19 pandemic on medical students in the United States. American Medical Student Association Convention, 2021
• Nicole Mitchell, Meg Wright Sidle, Joe Kingery The educational impact of the COVID-19 pandemic on medical students in the United States.University of Pikeville Research Symposium, 2021

2020:

• Siddiqui A, Ryan N, Anderson K, Volpedo G, Mellen L, Oghumu S. Conditional removal of myeloid cell-derived MIF through a Cre-loxP system in mice. OSUCCC Annual Scientific Meeting. Columbus OH, October 13, 2020.
• Siddiqui A, Ryan N, Anderson K, Volpedo G, Mellen L, Satoskar A, Oghumu S. Cre-lox mediated conditional removal of myeloid cell-derived Mif in a mouse model of oral cancer. Virtual Autumn Undergraduate Research Festival. Columbus Ohio, November 2-6, 2020. (http://hdl.handle.net/1811/92108)
• Siddiqui A, Ryan N, Anderson K, Volpedo G, Mellen L, Oghumu S. Myeloid cell specific Mif knockout induced by Cre-LoxP in a mouse model. Pelotonia Institute for Immuno Oncology Symposium. Columbus, Ohio, November 2, 2020.
• Siddiqui A, Ryan N, Anderson K, Volpedo G, Mellen L, Satoskar A, Oghumu S. Cre-LoxP induced deletion of Macrophage Migration Inhibitory Factor in myeloid cells. The Ohio State University’s Center for Clinical and Translational Science’s 8^th Annual Scientific Meeting. Columbus Ohio, January 19, 2020.
• Ryan N, Anderson K, Siddiqui A, Swingler M, Oghumu S. Macrophage migration inhibitory factor promotes anti-tumoral T cell differentiation within the tumor microenvironment. OSUCCC Annual Scientific Meeting. Columbus OH, October 13, 2020.
• Ryan N, Anderson K, Siddiqui A, Swingler M, Oghumu S. Macrophage migration inhibitory factor promotes an anti-tumoral cellular response in head and neck squamous cell carcinoma. Pelotonia Institute for Immuno Oncology Symposium. Columbus, Ohio, November 2, 2020.
• Anderson K, Ryan N, Alkhimovitch A, Siddiqui A, Oghumu S. Host PI3K-Gamma Inhibition Significantly Modulates Immune Activity at the Tumor Site of Poorly Immunogenic Head and Neck Cancer. Pelotonia Institute for Immuno Oncology Symposium. Columbus, Ohio, November 2, 2020.
• Anderson K, Ryan N, Pero T, Siddiqui A, Cooperstone J, Oghumu S. Black Raspberries Elicit Potent Anti-Inflammatory and Contribute to a Reduction in T-cell Driven Contact Hypersensitivity. Russell Klein Nutrition Research Symposium, Columbus OH, March 31, 2020.
• Ryan N, Anderson K, Siddiqui A, Pero T, Celano A, Cooperstone J, Oghumu S. Inflammation is attenuated by black raspberry metabolites in a murine model of allergic contact dermatitis. OSU Wexner Medical Center Trainee Research Day, Columbus OH, April 16, 2020.
• Jones, R.N., Erhard S.A., Malham, M.R., Gen, A.Y., Sullivan, K., Olsen K.W., Dale, R.M., (2020, March 01). Expression and Functional Characterization of Zebrafish Folate Receptor 1 During Embryogenesis [Oral Presentation]. University of Pikeville- KYCOM/KYCO Research Day /Pikeville , KY, USA.
• Rupani, R , Lui, A, Bader, D, Patel, N. Pro Survival PKC δ VIII Regulates. Ovarian Cancer Progression. Location: University of South Florida Research Day, 2020.
• Yacques, A. & Bates, R. (2020, July 6-9). Associations between cortisol levels and sleep behavior in infants and toddlers up to 36 months of age [Virtual poster presentation]. International Congress of Infant Studies (ICIS) 2020 biennial conference, held virtually due to COVID19. https://infantstudies.org/wp–content/uploads/2020/07/vICIS–Posterpdf

2019:

• Andrew Abadier OMS-III, Michael Abadier DO, John Abadier MD, Pancreatic Adenocarcinoma Presenting as Acute Large Bowel Obstruction. American College of Gastroenterology Annual Conference in San Antonio, TX
• Hamm B, Pramanik K. Pseudolaric Acid B (PAB) Induces Senescence by Activation of P53/P21 Pathway in Pancreatic Cancer Cells. JAOA. 2019 Dec;119(12): 46-143
• Samuel Potter, Jacob Sifers, Emily Yocom, Sandra L.E. Blumich, Rachel Potter, Jeremy Nadolski, Douglas A. Harrison, Robin L. Cooper, Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular, physiology and cardiac function in larval Drosophila: Biology open.
• Mustafa M. Basree, Neelam Shinde, Zaibo Li, Sarmila Majumder, Bhuvaneswari Ramaswamy. Analysis of healthy breast tissue from Komen tissue bank show distinct histology, decreased proliferation and lower periductal collagen deposition in women with prolonged history of breastfeeding. American Society for Clinical Oncology Annual Meeting in Chicago, IL. June 2019
• Shaun Hansel, Amber Crawford, Kartick C. Pramanik. Pseudolaric Acid B (PAB) Sensitizes Gemcitabine Efficacy Toward Pancreatic Cancer Cell Death by Targeting P53/P-GP Signaling Pathways, The Journal of the American Osteopathic Association, November 2018, Vol. 118, e101-e202. oi:10.7556/jaoa.2018.163
• Neelam Shinde, Mustafa Basree, Sivanesan Dhandayuthapani, Jianying Zhang, Resham Mawalkar, Gina M. Sizemore, Sarmila Majumder, Bhuvaneswari Ramaswamy. Tamoxifen Treatment Abolishes Pre-Cancerous Changes Induced By Abrupt Involution In Mouse Mammary Glands. Great Lakes Breast Cancer Research in Columbus, OH. May 2019
• Megan Smith, D.O., Parth Shah, MS4., Chen Rubinstein, M.D., Jacqueline Dawson Dowe, M.D., Mohammad Abdul-Waheed, M.D. Snared: Percutaneous Retrieval of Intracardiac Migrating Foreign Body. Bowling Green, KY at the Western Kentucky Heart and Lung Symposium