Michael Younger, Ph.D.

Associate Professor of Biochemistry

  • Office: Coal Building, 716
  • Telephone: (606) 218-5417
  • E-mail: MichaelYounger@upike.edu

OST-503 Medical Biochemistry, KYCOM-UPIKE
BIO-499 Upper Lvl Biological Research Course Development, UPIKE
CHE 471 Advanced Chemical Research, UPIKE
OPT517 Genetics, Biochemistry, and Metabolism
OPT 616 Ocular Physiology and Biochemistry
OPT 528 Neuroanatomy and Neuroscience
OPT 728 Optometry Review

University of North Carolina-Chapel Hill
Chapel Hill, NC
Ph.D. in Cell & Developmental Biology
Dissertation: Selection of Misfolded CFTR for Proteasomal Degradation by Sequential Quality Control Checkpoints.

Lindsey Wilson College
Columbia, KY
Bachelor of Arts in Biology, Summa Cum Laude

Nuclear Propulsion Machinist MM5
Naval Nuclear Propulsion Prototype Training Facility, Balston Spa, NY
Nuclear Propulsion Plant Operator, Naval Reactors Division, Nuclear Regulatory Commission

Nuclear Propulsion Machinist MM4
Naval Nuclear Power Training Program, Orlando, FL
Nuclear Power, Materials, Water Chemistry, Heat Transfer & Fluid Dynamics Training Program

Kenneth, N.S., Younger, J.M., Hughes, E., Saunders, T., Duckett, C.S. (2012) An Inactivating Caspase-11 Passenger Mutation Originating from the 129 Murine Strain in Mice Targeted for c-IAP1. Biochem. J. 15;443(2):355-9.

Younger, J.M., Chen, L., Ren, H.Y., Rosser, M., Turnbull, E., Fan, C.Y., Patterson, C., Cyr, D.M. (2006) Sequential Quality-control Checkpoints Triage Misfolded Cystic Fibrosis Transmembrane Conductance Regulator. Cell. 126(3):571-82.

Younger, J.M., Fan, C.Y., Chen, L., Rosser, M.F., Patterson, C., Cyr, D.M. (2005) Use of the Cystic Fibrosis Transmembrane Conductance Regulator as a Model Substrate to Study Endoplasmic Reticulum Protein Quality Control in Mammalian Cells; Methods in Molecular Biology: Ubiquitin-Proteasome Protocols, 301:293-303. Humana Press Inc. Totowa, New Jersey

Younger, J.M., Ren, H.Y., Chen, L., Fan, C.Y., Fields, A., Patterson, C., Cyr, D.M. (2004) A Foldable CFTR(Delta)F508 Biogenic Intermediate Accumulates Upon the Inhibition of the Hsc70-CHIP E3 Ubiquitin Ligase. J. Cell Biol. 167:1075-1085.

Meacham, G.C., Patterson, C., Zhang, W., Younger, J.M., Cyr, D.M. (2001) The Hsc70 Co-chaperone CHIP Targets Immature CFTR for Proteasomal Degradation. Nature Cell Biology 3:100-105.

Research Fellowships:

Michigan State University, East Lansing, MI
Department of Biochemistry and U.S. Plant Research Laboratory
Post Doctoral BioEnergy Research / Research Associate: U.S. Department of Energy: Great Lakes Bioenergy Research Center

University of Michigan, Ann Arbor, MI
Departments of Pathology and Pulmonary Immunopathology Joint Appointment
Postdoctoral Medical Research