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Cell & Molecular Biology
Ph.D. – Natural Sciences
Children’s Memorial Health Institute and A.K. Military Institute of Hygiene and Epidemiology
MSc – Molecular Biology and Biochemistry
Sachdeva, R., Sharma, Y., Shilpi, R.Y., Li, Y., and Simm, M.: Human DING protein mediates cellular innate immunity response to HIV-1 infection through the paracrine signaling. FEBS J. 282(5):937-350, 2015.
Sachdeva, R., Shilpi, Y.R., and Simm, M.: The interplay between the X-DING-CD4, IFN-α and IL-8 gene activity in quiescent and mitogen or HIV-1 exposed PBMCs from HIV-1 elite controllers, AIDS progressors and HIV(1) controls. Innate Immun. 20(2):173-183, 2014.
Sachdeva, R., Darbinian, N., Khalili, K., Amini, S., Gonzales, D., Djeghader, A., Chabreire, E., Suh, A., Scott, K., and Simm, M.: DING proteins from phylogenetically different species share a common anti-HIV activity. PLoS One 8: e69623, 2013.
Ivanova, A., Shilpi, Y.R., Sachdeva, R., Li, G., and Simm, M.: Native X-DING-CD4 protein secreted by HIV-1 resistant CD4+ T cells blocks activity of IL-8 promoter in human endothelial cells infected with enteric bacteria. Innate Immun. 18(4):571-579, 2012.
Shilpi, Y.R., Sachdeva, R., and Simm, M.: Cellular resistance to HIV-1 infection in target cells coincides with a rapid induction of X-DING-CD4 mRNA; indication of the unique host innate response to virus regulated through function of the X-DING-CD4 gene. Innate Immun. 18(4):563-570, 2012.
Postdoctoral Fellow; Department of Pathology, Molecular Virology Division, Columbia University, New York
European Molecular Biology Organization (EMBO) – A Short-Term Fellowship Award for outstanding Ph.D. Candidate. Immunochemical and molecular genetic analysis of bacterial pathogens and their virulence determinants in Trinity College, Dublin, Ireland.
Immunology, Innate Immunity, Intrinsic factors mediating resistance to viral infections.