Dana C. Shaffer, D.O., FACOFP dist., FAOGME

Dean, Kentucky College of Osteopathic Medicine
Professor of Family Medicine

Office: Coal Building 602
Telephone: 606.218.5501
E-mail: DanaShaffer@upike.edu

Doctor of Osteopathic Medicine
Philadelphia College of Osteopathic Medicine

Bachelor of Science, Biology with minors in Chemistry and Philosophy
Wilkes University

Fellow of the American College of Osteopathic Family Physicians, 1997
Distinguished Fellow of the American College of Osteopathic Family Physicians, 2013

After graduating in 1985 from the Philadelphia College of Osteopathic Medicine, Dr. Dana Shaffer completed a rotating osteopathic internship at Des Moines General Hospital. For the next 22 years he practiced the complete spectrum of rural family medicine, including OMM, OB, and ER, as well as both inpatient and outpatient medicine in Exira, Iowa. Dr. Shaffer has been involved in teaching medical students for more than 22 years at many levels.

Over his career, Dr. Shaffer has served on numerous local, state and national committees and taskforces dealing with access to affordable medical care, scope of practice issues, use of chronic pain medication, electronic medical records, and legislation. Very active in community service, he has served as the Medical Director of a rural nursing home, free clinic, and EMS rescue squad.

Dr. Shaffer has been married for more than 34 years and has two children and two grandchildren.

American Board of Osteopathic Family Physicians (ABOFP); 1993
Recertified in Osteopathic Family Medicine by ABOFP; 2013

Pikeville Medical Center
Preceptor in the Family Medicine Residency Program

Daniel H. Atchley, Ph.D., M.S., MT-ASCP

Associate Dean for Basic Sciences
Professor of Microbiology and Immunology

Office: Coal Building
Telephone: 606.218.5502
E-mail: DanielAtchley@upike.edu

Optometry College Courses
  • Immunology and Microbiology
  • Pathology and Disease Processes
Osteopathic Medical College Courses
  • Medical Microbiology
  • Medical Immunology
  • Medical Physiology (select topics)
  • Osteopathic Patient Care (select topics and skills)
Pharmacy Courses
  • Advanced Pharmacy Practice Electives (research electives & Health & Wellness)
  • General Pathophysiology (Immunopathology Primer, Acid-Base Disorders, Renal Disorders, RBC Disorders, WBC Disorders, Hypersensitivities, Antibody-based Therapeutics, Nutrition Disorders, Diabetes mellitus)
  • Introductory Pharmacy Practice Electives (Charitable Clinic Lab shadowing/Pharmacy-Service Learning)
  • Medical Immunology (all lectures)
  • Medical Microbiology (all lectures)
  • Pharmacology (Mechanisms of bacterial infection, Mechanisms of viral infection)
  • Research Electives
  • World Diseases (HIV, STIs)
Physician Assistant Courses
  • Clinical Medicine (Blood Constituents, Immunity and    Inflammation, Introduction to Infectious Diseases, Mechanisms of Infectious Diseases, Acid-Base Disorders, Hematopoietic System, Disorders of Hemostasis, Endocrine Control)
  • Clinical Skills (Introduction to Laboratory Medicine,              Phlebotomy, IV skills, Laboratory medicine II)
Undergraduate Courses (US Air Force Academy)
  • Extensive experience teaching 13 undergraduate biology, communication, and humanities courses; and mentoring students

Doctor of Philosophy, Microbiology & Immunology
Medical University of South Carolina, Charleston, S.C.

Masters of Science, Laboratory Medicine/Clinical Chemistry
University of Washington, Seattle, Wash.

Bachelor of Science, Medical Technology
Northeastern State University, Tahlequah, Okla.

Associate of Science, Biology
Tulsa Junior College, Tulsa, Okla.

American Society for Clinical Pathology
     Medical Technologist/Medical Laboratory Scientist (ASCP ID 02391811)

Outstanding Educator of the Year
Kentucky College of Osteopathic Medicine, 2014

Teacher Achievement Award for Teaching Excellence
Harding University, 2012

Frank J. Seiler Award for Research Excellence
US Air Force Academy, 2006

Outstanding Academy Educator Award for Teaching Excellence
US Air Force Academy, 1998

Promethean Educational Leadership Award for Teaching Excellence
US Air Force Academy, Department of Biology, 1997

Gregory, B.J., Chen, S.M., Murphy, M.A., Atchley, D.H., Kamdem, L.K. (2017).  Impact of the OATP1B1 c.521T>C single nucleotide polymorphism on the pharmacokinetics of exemestane in healthy post-menopausal female volunteers. Journal of Clinical Pharmacy and Therapeutics. 2017:42(5): 547–553 (Online: 29 JUL 2017, DOI: 10.1111/jcpt.12569)

Chen, S.M., Atchley, D.H., Murphy, M.A., Gurley, B.J., Kamdem, L.K. (2016). Impact of Impact of UGT2B17 Gene Deletion on the Pharmacokinetics of 17-hydroexemestane in Healthy Volunteers. J. of Clin. Pharm, 56(7):875-884 (Online: Dec 2015)

Lee, Y., Atchley, D.H., Proctor, C.A., Smith, F.L., Yi, S., Loftis, C., Yates, K.M. (2015). Time Kill Kinetics of a Novel Antimicrobial Silver Wound Gel Against Select Wound Pathogens. Wounds: A Compendium of Clinical Research and Practice. Wounds 2015;27(12):336-346

Craig D. Nowadly, Jason W. David, Melanie L. M. Grogger, Erik R. Demkowicz, Daniel H. Atchley, Donald V. Veverka (2014). Characterizations of the effects of heat stress on the DNA-intercalating dye EvaGreen for potential use with the Joint Biological Agent Identification and Diagnostics System (JBAIDS). Military Medicine, 179(6):580-e718

Odreman-Macchioli, M., Vielma, S., Atchley, D., Comach, G., Ramirez, A., Perez, S., Tellez, L., Quintero, B., Hernandez, E., Munoz, M., Mendoza, J. (2013). Analysis of real-time pcr amplification efficiencies from three genomic regions of dengue virus.  Investigacion Cientififica, 54(1):5-19

Hall, P. D., Weimert, N. A. , & Atchley, D. H. (2011). Function and Evaluation of the Immune System,  In J.T. Dipiro (Ed.), Pharmacotherapy: A Pathophysiological Approach (pp. 1487 - 1504). New York:  McGraw Hill. 

Reiman, R. W., Atchley, D. H., & Voorhees, K. J. (2007).  Indirect detection of Bacillus anthracis using real-time PCR to detect amplified gamma phage DNA.  Journal of Microbiological Methods.  

McAvin, J. C., Bowles, D. E., Swaby, J. A. , Blount, K. W. , Blow, J. A. ,  Quintana, M., Hickman, J.R., Atchley, D.H., Niemeyer, D.M. (2005).  Identification of Aedes aegypti and its Respective Life Stages by Real-time PCR.  Military Medicine.
McAvin, J. C., Escamilla, E. M., Blow, J. A., Turell, M. J. , Quintana, M., Bowles,D.E., Swaby, J.A., Barnes, W.J., Huff, W.B., Lohman, Atchley, D.H., Hickman, J.R., Niemeyer, D.M. (2005).  Rapid identification of dengue virus by RT-PCR using field-deployable instrumentation.  Military Medicine.  

Daum, L. T., Kruzelock, R. P., Ye, K., Hickman, J. R., Chambers, J. P., Barnes, W.J., Atchley, D.H. (2004).  Comparison of taqman and epoch dark quencher hydrolysis probes during real-time reverse transcriptase pcr.  Molecular and Cellular Probes.  

McAvin, J. C., Morton, M. M., Roudabush, R., Atchley, D. H., & Hickman, J. R. (2004).  Identification of Francisella tularensis using real-time fluorescence PCR.  Military Medicine.  

Azzimonti, F., Atchley, D. H., Morrison, C. A., Dodd, S., Boulton, D. W. , DeVane, C.L., Arnaud, P. (2003).  One step purification of alpha(1)-acid glycoprotein from human plasma. Fractionation of its polymorphic allele products.  Journal of Chromatography B Analytical Technology Biomedical Life Science, 784, 33-38.  

Virella, G. H., Thorpe, S., Alderson, N. L., Stephan, E. M., Atchley, D. H., Wagner, F., Lopes-Virella, M., and the DCCT/EDIC Research Group, (2003).  Autoimmune response to advanced glycosylation end products of Human LDL.  Journal of Lipid Research.  

Anderson, F., Game, B., Atchley, D. H., Xu, M., Lopes-Virella, M., Huang, Y. (2002).  IFN-gamma fusion toxin pretreatment augments immune complex-induced matrix metalloproteinase-1 expression in U937 histiocytes.  Clinical Immunology.  

Atchley, D. H., Lopes-Virella, M. F., Aheng, D., Kenny, D., & Virella, G. (2002).  Oxidized LDL-anti-oxidized LDL immune complexes and diabetic nephropathy.  Diabetologia.  

Burnham, B. R., Atchley, D. H., Defusco, R. P. , Fowler, J., Darling, M. J. , Angulo, F.J. (2002).  The use of enrofloxacin to prevent shedding of Salmonella from Green Iguanas, Iguana iguana.  Journal of Herpetological Medicine and Surgery, 12 (2), 10-13.  

Virella, G., Atchley, D. H., Koskinen, S., Zheng, D., Lopes-Virella, M. F., DCCT/EDIC Research Group, (2002).  Proatherogenic and proinflammatory properties of immune complexes prepared with purified human oxLDL Antibodies and human oxLDL.  Clinical Immunology.  

Hall, P., Virella, G., Willoughby, T., Atchley, D. H., Kreitman, R., Frankel, A. (2001).  Antibody response to DT-GM during a phase I trial of patients with relapsed or refractory acute myeloid leukemia.  Clinical Immunology.  

Hirsch, I., Atchley, D. H., Tsai, E., Labbe, R., & Chait, A. (1998).  Ascorbic acid clearance in diabetic nephropathy.  Journal of Diabetes & its Complications.  

Burnham, B., Atchley, D. H., DeFusco, R., Ferris, K., Zicarelli, J., Lee, J., Angulo, F. (1998).  Prevalence of fecal shedding of Salmonella organisms among captive green iguanas and potential public health implications.  Journal of the American Veterinary Medical Association.  

Dan Atchley was born in San Manuel, Arizona, where he lived until his family emigrated to Australia when he was 12-years-old. After four years in the Western Australian Outback, he moved to Okemah, Oklahoma to finish high school, and went on to serve 21 years in the military, with 3 years as an US Army Medical Laboratory Specialist, at Ft Hood, Texas; and 18 years as an US Air Force Biomedical Sciences Corp Officer serving in various educational, research, clinical and advisory leadership roles.

After retiring from the US Air Force, Dr Atchley served as an Associate Professor of Pharmaceutical Sciences and Director of Assessment at Harding University College of Pharmacy, Searcy, Arkansas, where he directed the college’s assessment efforts, taught basic medical sciences and conducted biomedical research.

He came to Pikeville, KY in 2013, and currently serves as the Associate Dean for Basic Sciences and Associate Professor of Microbiology and Immunology, where his responsibilities include oversight of the preclinical didactic disciplines, teaching basic medical sciences and conducting biomedical research. Dr Atchley enjoys hiking, SCUBA diving, and spending time with family and friends.

He, and his wife, Kim, also enjoy traveling, especially to visit their children and grandchildren in Charleston, SC and Searcy, AR.

Teaching Philosophy: The best indicator of effective teaching is student learning. In order to accomplish this, a teacher should engage the student in an active learning environment that provides relevant and focused information, with real-world applications. Although I rely heavily on Power Point to keep me on track and guide classroom presentations, I believe students need active engagement strategies to maximize their learning. To this end, I emphasize transparent learning objectives that guide the students to what I expect them to know and do with the information presented and discussed in class. In a typical classroom session, I employ a healthy dose of direct and indirect questions (via an audience-response system) and provide students with fill-in-the blank note-takers to encourage at least a minimal level of participation. I utilize mnemonics to help students create mental pegs for complex information. For example, ‘ROME’ helps students sort through acid-base disorders. Respiratory disorders cause blood pH and pCO2 go opposite directions (respiratory is opposite), and metabolic disorders cause them to go equal directions (metabolic is equal). I have also found learning to be enhanced with periodic demonstrations (for kinesthetic learners), videos (accompanied by clear questions and objectives), in-class exercises, real life case studies, and group presentations. Most recently, I have been experimenting with team-based-learning to determine how to best utilize it inside and outside the classroom.

Boris Boyanovsky, MD, Ph.D.

Associate Professor of Anatomy

Office: Coal Building 815
Telephone: 606.218.5486
E-mail: BorisBoyanovsky@upike.edu


MD - Medical University of Sofia, Bulgaria
PhD – Alexander’s University Hospital, Sofia, Bulgaria

Boris Boyanovsky is a native of Bulgaria. He joined the KYCOM faculty in July 2015. Before KYCOM he was a Research Assistant Professor at the University of Kentucky in Lexington, KY.  Boris is a physician by heart and education. In the US he has devoted his career to teaching medical students. On a personal basis he enjoys travelling to exotic places, ski, snorkeling, karate, and spending time with his family.

Michael Carnes, DO, FAAO

Associate Professor of Osteopathic Principals and Practices 

Office: Coal Building 912
Telephone: 606.218.5449
E-mail: MichaelCarnes@upike.edu

Osteopathic Principals and Practices

Residency in Osteopathic Manipulative Medicine 
St. Barnabas Hospital, Bronx, NY

Doctor of Osteopathic Medicine
Des Moines University, Des Moines, IA

Bachelor of Arts in Chemistry
Bethany College, Lindsborg, KS

Dr. Carnes has been involved with developing and running residency programs in NMM-OMM on local, state, and national levels since completing his residency training program in 2000.

Fellow of the American Academy of Osteopathy 2008
Educator of the Year – Mercy General Health Partners 2003-2004
Wyeth Emerging Leaders Award – American Osteopathic Foundation 2002
UNT-HSC Outstanding Student Organization Advisor (UAAO) 2001-2002

American Osteopathic Board of Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine

Joshua Crum, D.O.

Associate Dean for Clinical Affairs
Assistant Professor of Family Medicin

Office: Coal Building 611
Telephone: 606.218.5428
E-mail: JoshuaCrum@upike.edu

Diagnostic Radiology Residency
Grandview Medical Center, Dayton, Ohio

Internship/Internal Medicine Residency
Norton Community Hospital, Norton, Virginia

Doctor of Osteopathy
Pikeville College School of Osteopathic Medicine

Major Biology, Minor Chemistry
Pikeville College


Danny Driskill, J.D., NRP, FP-C

Director of Simulation 
Instructor, Department of Family Medicine

Office: Coal Building 442
Telephone: 606.218.5448
E-mail: DannyDriskill@upike.edu

The son of a pilot and a special education teacher from Tulsa, Okla., Dan Driskill grew up on U.S. Air Force bases and near Western Airlines airports in Kansas, Alabama, Georgia, Florida, Washington, Colorado and California.

Driskill graduated from California State University Fullerton with a bachelor's degree in linguistics in 1984, studying French, German, Japanese, Sanskrit, and New Testament Greek as well as language structure and development. While waiting to start law school at the University of California Davis, he completed Emergency Medical Technician and Spanish classes at a local community college.

His law school classmates spent their summers as law clerks; Driskill served on the Yolo County, California, Emergency Services Council, worked as an EMT, and studied the Chinese language and legal system in Shanghai.

Driskill worked for several years as a litigation attorney, legal writer and legal software author before beginning his new career as a paramedic in Los Angeles and working briefly as a firefighter-paramedic near Palm Springs. He moved to Truth or Consequences, N.M., in 1997 and was pleasantly surprised to learn that rural emergency medicine offered even more challenges and rewards than the urban environs of Southern California.

During Driskill's seven years there he served as a paramedic, paramedic supervisor, regional training officer, and eventually owner/operator of a small ambulance service whose 911 coverage area was larger than Los Angeles County. He also got his first taste of air medicine in Southern New Mexico and West Texas, occasionally accompanying patients aboard the Army’s MAST helicopters when their flight crews did not include a paramedic-level crewmember.

Driskill began work for Northern Arizona Healthcare/Guardian Air in 2004, serving as a flight paramedic aboard both helicopters and fixed-wing aircraft, and incorporating the use of high-fidelity robotic simulation into his healthcare education activities. In 2011, Driskill married an Arizona suburbanite turned Kentucky small farmer and moved to Eastern Kentucky, where he continued to serve as a flight paramedic and regional healthcare educator.

Prior to becoming KYCOM’s director of simulation, Driskill taught BLS and ACLS to second-year medical students for three years, and worked for a year as a standardized patient and OSCE grader.

He enjoys spending his free time with his wife Catherine and their children, friends, and family; attending church; reading; writing; hiking; and small-farming/large-gardening.

Laura Griffin, D.O., FAAO

Professor & Chair, Dept. of Osteopathic Principles and Practices 
Assistant Dean of Osteopathic Principles and Practices Integration

Office: Coal Building 906
Telephone: 606.218.5434
E-mail: LauraGriffin@upike.edu



Osteopathic Principles and Practices

Doctor of Osteopathic Medicine
University of New England College of Osteopathic Medicine

Bachelor of Science in Biology
State University of New York at New Paltz

Dr. Griffin is a native of Red Hook, N.Y., but lived in Maine for nine years while attending medical school and completing her residency. She then lived in Grand Rapids, Mich., for seven years while teaching at Metro Health Hospital, before moving to Pikeville in 2008 to join Dr. Buser and the faculty at KYCOM. Dr. Griffin enjoys movies, reading, making stained glass artwork, cooking, gardening, spending time with family and her cat and sheepdogs.

Fellow, American Academy of Osteopathy, 2009
Faculty Member of the Year, Pikeville College School of Osteopathic Medicine Student Advocate Association, 2009

Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine
Family Medicine

Steven R. Harris, Ph.D.

Associate Dean for Academic Affairs
Professor of Pharmacology & Physiology

Office: Coal Building 303
Telephone: 606.218.5422
E-mail: StevenHarris@upike.edu

Human Physiology
Medical Pharmacology
Molecular Pharmacology

Postdoctoral Training
National Cancer Institute

Doctor of Philosophy in Pharmacology & Toxicology
University of Georgia

Masters of Science in Pharmacology & Toxicology
Auburn University

Bachelor of Arts in Biology and Chemistry
LaGrange College

Staff Member of the Year, Pikeville College School of Osteopathic Medicine, 2008
Teaching Excellence Award, Kentucky College of Osteopathic Medicine, 1999-2015
SAA Award for Outstanding Support, Kentucky College of Osteopathic Medicine, 2008, 2010, 2011, 2015
Administrator of the Year, Kentucky College of Osteopathic Medicine, 2003-2005

Dr. Harris was born in North Carolina but lived most of his life in Georgia. Following postdoctoral training at the National Cancer Institute, he moved to Pikeville in 1998 to organize and teach the medical pharmacology course at KYCOM. Since that time he has taken on administrative responsibilities as associate dean for Basic Sciences from 2002-2008, and as associate dean for Academic Affairs from 2008-present. He enjoys various sports activities including golf, football, baseball and basketball, as well as spending time with his wife, Barbara, and kids.

Ingrid Herrmann, Ph.D.

Assistant Professor of Pathology for KYCOM 

Office: Coal Building 818
Telephone: 606.218.5425
E-mail: IngridHerrmann@upike.edu

Dr. Herrmann joined KYCOM in 2013 with a desire to teach/serve with the medical school’s mission in bringing medicine to the mountains in the rural and underserved areas of Kentucky and Appalachia. The kindness of the local people and the beauty of the mountains have taken her breathe away.

Dr. Herrmann has been successfully teaching students in the health/medical sciences for over 15 years. Although she found her love for teaching early when she was teaching high school sciences in the mid 90’s, Dr. Herrmann had wanted to teach at the medical school level since the age of 17.

Dr. Herrmann has focused her teaching in the health/medical sciences in courses such as pathology, microbiology, immunology, pharmacology, nutrition, anatomy & physiology and biology. Instead of pursuing a Ph.D, Dr. Herrmann decided to get a Medical Degree and more recently a Masters Degree in Public Heath to be effective in teaching students who are entering the health professions. Therefore all the classes she teaches will have a clinical twist as she gets students to already start thinking about the patient.

Dr. Herrmann has also enjoyed doing independent consulting work for medical education programs for colleges and universities in the US and overseas. For example she has taught online medical school courses at Oceania University of Medicine which is based out of Samoa.

Teaching runs in the family as virtually everyone in her family teaches or has taught from elementary school to graduate school level. Since both of her parents have held teaching and senior level management positions in colleges and universities it has given her an excellent perspective in management and student centered teaching/ learning as well. Dr. Herrmann’s father also served in the Appalachian region in university administration.
In the classroom setting Dr. Herrmann is known as a student advocate. She loves to have an open learning environment where students can always ask questions. Student success is very important to Dr. Herrmann. She also enjoys motivating students to achieve their very best.

In 2010, Dr. Herrmann graduated with an online Masters in Public Health from Florida International University with a special certificate in Health Promotion and Prevention.
In 2001, Dr. Herrmann graduated with a Medical Degree (Physician and Surgeon Diploma) from the International Program School of Medicine at Universidad Autonoma de Guadalajara. Dr. Herrmann has a BS in Microbiology from the University of Florida. She also has post graduate work (21 hours) in Nutrition and Biochemistry from UF.
For scholarly activities, Dr. Herrmann wants to continue writing/authoring textbook supplementals and/or textbooks in the health and medical sciences for example, she authored an Instructor Preparation Guide, for McGraw Hill Publishing, to accompany Cowan, Microbiology Fundamentals: A Clinical Approach, first edition, ©2012.
Dr. Herrmann loves to spend time with her husband and pets (fukids).


Antoinette Justice, D.O.

Assistant Professor of Family Medicine and Osteopathic Principles and Practices 

Office: Coal Building 435
Telephone: 606.218.5432
E-mail: AntoinetteJustice@upike.edu

Family Medicine
Osteopathic Principles and Practices

Doctor of Osteopathic Medicine
Pikeville College School of Osteopathic Medicine, Pikeville, Ky., 2010

Osteopathic Manipulation Treatment Fellowship
Pikeville College School of Osteopathic Medicine, Pikeville, Ky, 2007-2008

Bachelor of Science in Biology, Minor: Chemistry
University of Virginia, College at Wise, Wise Va., 2003

Humanism and Excellence in Teaching Award Winner, 2012
John A. Strosnider, D.O., Memorial Scholarship Award, 2010
Ram’s Head Award for Fellowship Program, 2010

Dr. Antoinette Justice is a native of the Appalachian area of Eastern Kentucky.   She grew  up and attended elementary and high school  at Elkhorn City, Kentucky which is just south of Pikeville, Kentucky.  She comes to KYCOM after completing a Family Medicine and Neuromuscular Medicine residency at Pikeville Medical Center, July 2014.  Along with her teaching duties, she supervises and precepts the Family Medicine Residents at Pikeville Medical Center in the Family Practice Clinic. Dr. Justice is married and has 3 children. She enjoys camping and being outdoors, cooking, gardening and   singing as well as spending time with her family and pets.

Joe Kingery, D.O., CPE, FAAFP

Associate Professor and Chair, Department of Family Medicine

Office: Coal Building 435
Telephone: 606.218.5446
E-mail: JoeKingery@upike.edu

Family Medicine

Doctor of Osteopathic Medicine
Kentucky College of Osteopathic Medicine

Bachelor of Science in Biology
University of Kentucky

Fellow Award, American Academy of Family Physicians; 2016

Abraham Flexner Master Educator Award for excellence in teaching, University of Kentucky College of Medicine, 2015

American Board of Family Medicine (ABFM); 2009
American Osteopathic Board of Family Physicians (AOBFP); 2009

Kingery J., Taylor W., Braun D. Acute Otitis Media. Osteopathic Family Physician. November/December 2016.

Kingery J., Akins R., Bobrowski B. Dysuria. Osteopathic Family Physician. July/August 2016

Kingery J. Urinary Tract Infections. Current Diagnosis and Treatment in Family Medicine. 2015. The McGraw Hill Companies, Inc. Chapter 22: 229-239.

Matheny S. and Kingery J. Hepatitis A. American Family Physician. 2012 Dec 1:86(11):1027-1033. (PMID: 23198670; Impact Factor 1.82)

Kingery J. and Noble W. Endometrial Biopsy. Osteopathic Family Physician. 2012 Sep; 4(5):144-148.

King M., Kingery J., and Casey B. Diagnosis and Evaluation of Heart Failure. American Family Physician. 2012 Jun 15; 85(12):1161-1168. (PMID: 22962896; Impact Factor 1.82)

Joe E. Kingery is a native of rural Kentucky and is a 2006 graduate of the Kentucky College of Osteopathic Medicine. Kingery completed his family medicine residency at the University of Kentucky in Lexington, Ky., in 2009. Following residency, Kingery served as teaching faculty and practicing physician at the UK East Kentucky Family Medicine Residency from 2009 to 2016. He also served as the medical director and executive director of the clinic for more than five years.

Kingery returned to UPIKE-KYCOM due to his passion and desire to teach and be more involved with medical education. His hobbies include camping and hiking.

Kartick Pramanik, Ph.D.

Assistant Professor of Pharmacology

Office: Coal Building M 11
Telephone: 606.218.5423
E-mail: kartickpramanik@upike.edu



Postdoctoral training in Cancer pharmacology
Texas tech University HSC
Penn State University

Doctor of Philosophy in Pharmacy (Con.- Pharmacology)
Jadavpur University, India

Masters in Pharmacology
Jadavpur University, India

Bachelor of Pharmacy
Jadavpur University, India

Medical Pharmacology
Molecular Pharmacology

“Recognizing Research Excellence” Texas Tech University HSC, Texas, 2012
“Excellence in Postdoctoral Research” Texas Tech University HSC, Texas, 2011
 “1st prize in poster presentation” Texas Tech University HSC, Texas, 2010
“UGC Research Fellowship in Sciences Meritorious student” award, India 2007
“FESCI award” from 8th Congress of Chemotherapy and Infection, Budapest 2006
“Gold Medal” award Jadavpur University, India, 2006

1.Kartick C. Pramanik, Neel M. Fofaria, Parul Gupta, Alok Ranjan, Sung-Hoon Kim, Sanjay K. Srivastava. Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: Critical role of STAT-3, Oncotarget, 2015, 6(13): 11561–11574
2.Pramanik KC, Fofaria NM, Gupta P, Srivastava SK. CBP mediated FOXO-1 acetylation inhibits pancreatic tumors growth by targeting SirT-1. Molecular Cancer Therapeutics (MCT) 2014, 13(3):687-98.
3.Kartick C Pramanik, Pandey AK. Natural Compounds: Prospective of chemoprevention. Endocrinol Metab Synd (2013) 2: e115. doi:10.4172/2161-1017.1000e115.
4.Kartick C Pramanik, Pandey AK. Critical Role of Oxidant and Anti-oxidant in Cancer. Molecular Biology (2013) 2: e110. doi:10.4172/2168-9547.1000e110.
5.Kartick C Pramanik, Shashi Kudugunti, Neel Fofaria, Majid Moridani, Sanjay K. Srivastava. Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis 2013, 34(9):2061-70.
6.Reilly CA, Henion F, Bugni TS, Ethirajan M, Stockmann C, Pramanik KC, Srivastava SK, Yost GS. Reactive Intermediates Produced from the Metabolism of the Vanilloid Ring of Capsaicinoids by P450 Enzymes. Chem Res Toxicol. 2013, 26, 55−66
7.Kartick C. Pramanik, Sanjay K. Srivastava. Apoptosis signal regulating kinase 1-Trx complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid Redox Signal (ARS). 2012. 15; 17(10):1417-32.
8.Kartick C. Pramanik, Sanjay K. Srivastava. Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One. 2011; 6(5):e20151, 1-16.
9.Srinivas Reddy Boreddy, Kartick C. Pramanik, Sanjay K. Srivastava. Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clinical Cancer Research. 2011; 17(7):1784-1795.
10.S. Ghosh, K. C. Pramanik, T. K. Chatterjee. in vitro Anti-oxidant Activities of Methanolic Root Extract of Tissue Cultured Pluchea indica. Pharmacognosy Magazine. 2008, 16(4), 174-181.
11.K. C. Pramanik, T. K. Chatterjee.  In vitro and in vivo antibacterial activities of root extract of tissue cultured Pluchea indica (L.) Less against bacillary dysentery. Pharmacognosy  Magazine, 2008, 14(4), 78-84.
12.R. Biswas, P. K. Dutta, B. Achari, D. Bondyopadhyay, M. Mishra, K. C. Pramanik, T. K. Chatterjee. Isolation of pure compound R/J/3 from Pluchea  indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica. Phytomedicine. 2007, (14), 534-537.

Book Chapters:
1.Kartick C Pramanik & Atreyi Maiti. Anti-inflamatory in Phytochemicals. Nutraceuticals and Functional Foods in Human Health and Disease Prevention” Pages 197–214. Print ISBN: 978-1-4822-3721-4, CRC Press/Taylor & Francis, 2016
2.Palika Datta, Kartick C Pramanik, Sudhir Mehrotra and Sanjay K. Srivastava. Capsaicin Mediated Oxidative Stress in Pancreatic Cancer. (ISBN: 9780124052055). Elsevier publication, 2014.
3.Kartick C. Pramanik, and Palika Datta, Sanjay K. Srivastava. Oxidative Stress by capsaicin in cancer Pages: 149-172, Springer Science, 2013.
4.Kartick C. Pramanik, Sanjay K. Srivastava: Role of capsaicin in Cancer Prevention. Pages-1-18. Springer Science, 2013.
5.Srinivas Reddy Boreddy, Kartick C. Pramanik, Sanjay K. Srivastava: Molecular Target of Benzyl isothiocyanates in Pancreatic Cancer. Chapter-11, Page-193-212. 2012. InTech.

Kartick Pramanik, Ph.D., was born in India and migrated to USA for higher education in 2009. After completing his postdoctoral training at Texas Tech University Health Sciences Center and Penn State University, he joined as assistant professor at department of pharmacology, Penn State College of Medicine, Hershey in 2015. He moved to University of Pikeville in 2017 and joined as assistant professor in the basic sciences department of KYCOM. Dr. Pramanik teaches medical pharmacology courses and actively involves in basic science research.

His research focuses on to develop natural, synthetic, or biologic compounds as chemo-preventive/therapeutic agents against pancreatic, lung cancer. His long-term research goal is to understand role of oxidant and anti-oxidant in cancer progression, chemo-resistance and metastasis.

Dr. Pramanik has authored more than 30 peer reviewed research articles, and book chapters in leading oncology journals. He has been serving as reviewer, board member and Guest Editor in several reputed journals. He is a member of the American Association of Cancer Research and Society of Toxicology. He loves to play soccer, badminton and spends time with his wife, Atreyi and daughter, Disha.

Cathryn J. Rehmeyer, Ph.D.

Associate Professor of Pathology 

Office: Coal Building 817
Telephone: 606.218.5431
E-mail: CathrynRehmeyer@upike.edu

Doctor of Philosophy, Plant Pathology
University of Kentucky (2005)

Dissertation: “Sequencing of chromosome ends and characterization of a telomere-linked helicase gene family in the rice blast fungus Magnaporthe

Master of Arts, Secondary Education with Biology Emphasis
Morehead State University (2003)

Bachelor of Arts, Teaching Biology, Music minor
Transylvania University (1995)

Starnes, J.H., D.W. Thornbury, C.J. Rehmeyer, I. Chuma, Y. Tosa, and M.L. Farman. (2012). Telomere-targeted retrotransposons in the rice blast fungus Magnaporthe oryzae: agents of telomere instability. Genetics. 191(2):389-406.

Rehmeyer, Cathryn J. (2011) Male circumcision and HPV studies reviewed by infection stage and virus type. Journal of the American Osteopathic Association. 2011;111(3 suppl 2):S11-S18.

Stajich, J.E., S.K. Wilke, D. Ahrén, C.H. Au, B.W. Birren, M. Borodovsky, C. Burns, B. Canbäck, L.A. Casselton, C.K. Cheng, J. Deng, F.S Dietrich, D.C. Fargo, M.L. Farman, A.C. Gathman, J. Goldberg, R. Guigó, P.J. Hoegger, J.B. Hooker, A. Huggins, T.Y. James, T. Kamada, S. Kilaru, C. Kodira, U. Kües, D. Kupfer, H.S. Kwan, A. Lomsadze, W. Li, W.W. Lilly, L.J. Ma, A.J. Mackey, G. Manning, F. Martin, H. Muraguchi, D.O. Natvig, H. Palmerini, M.A. Ramesh, C.J. Rehmeyer, B.A. Roe, N. Shenoy, M. Stanke, V. Ter-Hovhannisyan, A. Tunlid, R. Velagapudi, T.J. Vision, Q. Zeng, M.E. Zolan, P.J. Pukkila. (2010) Insights into evolution of multicellular fungi from the assembled chromosomes of themushroom Coprinopsis cinerea (Coprinus cinereus). Proceedings of the National Academy of Sciences of the United States of America. 107(26):11889-94.

Rehmeyer, C.J., W. Li, Kusaba, M. and M.L. Farman. (2009) The telomere-linked helicase (TLH) gene family in Magnaporthe oryzae: revised gene structure reveals a novel TLH-specific motif. Current Genetics. 55(3): 253-62.

Rehmeyer, C.J., W. Li, and M.L. Farman (2006) Organization of chromosome ends in the rice blast fungus, Magnaporthe oryzae. Nucleic Acids Research. 34 (17): 4685-701.

Dean, R.A., Talbot, N.J., Ebbole, D.J., Farman, M.L., Mitchell, T., Orbach, M.J., Thon, M., Kulkarni, R., Xu, J., Pan, H., Read, N.D., Lee, Y., Carbone, I., Brown, D., Soanes, D.M., Djonovic, S., Kolomiets, E., Rehmeyer, C.J., Li, W., Harding, M., Kim, S., Lebrun, M., Bohnert, H., Butler, J., Calvo, S., Ma, L., Nicol, R., Purcell, S., Nusbaum, C., Galagan, J.E., and Birren, B.W. (2005) Analysis of the genome sequence of the plant pathogenic fungus Magnaporthe grisea, the causal agent of rice blast disease. Nature. 434 (7036): 980-6.

Li, W., C.J. Rehmeyer, C. Staben, M.L. Farman. (2004) TruMatch – A BLAST post-processor that identifies and reports bona fide sequence matches. Bioinformatics. 21(9): 2097-8.

Li, W., C.J. Rehmeyer, C. Staben, M.L. Farman. (2004) TERMINUS – Telomeric End-Read Mining IN Unassembled Sequences. Bioinformatics. 21(8): 1695-8.

KYCOM Golden Apple Teaching Award, 2007, 2010, and 2011
Graduate Research Fellowship, National Science Foundation, 2003-2006
M.S. Fuller Travel Award for travel to the 2005 MSA annual meeting in Hilo, Hawaii, Mycological Society of America, 2005
Program for Excellence in Science awardee, AAAS/Science, 2004-2006
Travel award to present research at the 9th U.S.-Japan Seminar on Plant Pathogen
Interactions: Genomic and Genetic Analysis of Plant Parasitism and Defense, Shizuoka,
Shizuoka Prefecture, Japan, 2003
Benjamin Cummings Publishing Campbell Biology Prize, Second Place, 1994

Dr. Rehmeyer joined the KYCOM family in January 2006. In her free time, she enjoys playing music (primarily banjo and clarinet, among others), gardening, backpacking, and travel. She lives in Pikeville with her daughters, Vivian and Caroline.

Julia H. Smith, DHEd

Assistant Professor of Anatomy

Office: Coal Building 802
Telephone: 606.218.5401
E-mail: JuliaSmith@upike.edu

Tracy L. Soltesz, Ph.D.

Professor of Anatomy 

Office: Coal Building 821
Telephone: 606.218.5466
E-mail: TracySoltesz@upike.edu

Medical Terminology
Cell Biology and Developmental Microanatomy
Gross Anatomy
Medical Neuroscience

Doctor of Philosophy in Biomedical Sciences (Anatomy)
Marshall University School of Medicine

Master of Science in Biomedical Sciences (Anatomy)
Marshall University School of Medicine

Bachelor of Science in Biology
Carlow College

Gender Equity Award, American Medical Women’s Association, 1998
Class of 2003 Most Caring Professor Award, Marshall University, 2000

Dr. Soltesz is a native of Zelienople, Pa. She moved to Huntington, W.Va., to complete her graduate work and has remained in the region ever since completing her Ph.D. Dr. Soltesz started teaching at University of Pikeville in the undergraduate biology department in 2000. She moved to the Kentucky College of Osteopathic Medicine in 2007. She enjoys gardening, reading, needlepoint, music and movies. Dr. Soltesz and her husband, Dr. Harold Chittum, keep both marine and freshwater aquaria and enjoy spending time with their Boston terrier, Baxter, house rabbit Esther Bunny and cats Fran, Eddie, Bennie and Sophie.

Edward G. Stiles, D.O., FAAO

Professor of Osteopathic Principles & Practices

Office: Coal Building 621
Telephone: 606.218.5424
E-mail: EdwardStiles@upike.edu

Josh Watson, Ph.D.

Assistant Professor of Physiology

Office: Coal Building 816
Telephone: 606.218.5433
E-mail: JoshWatson@upike.edu


Postdoctoral Training, 2012-2015
Duke University

Ph.D. in Physiology and Biophysics, 2011
University of Louisville

M.S. in Physiology and Biophysics, 2008
University of Louisville

B.S. in Biology and Chemistry
Western Kentucky University

2016 - Present: Assistant Professor
Founding Faculty, Basic Sciences
Kentucky College of Optometry
University of Pikeville

2015 - Present: Assistant Professor
Basic Sciences
Kentucky College of Osteopathic Medicine
University of Pikeville

2015: Adjunct Professor
Department of Arts, Sciences and University Transfer
Durham Technical Community College

2014 - 2015: Adjunct Professor
Department of Math, Science and Wellness
Central Carolina Community College

2013 - 2015: Institutional NRSA Postdoctoral Scholar
Department of Medicine-Division of Cardiology
Duke University

2012 - 2013: Postdoctoral Associate
Department of Medicine-Division of Cardiology
Duke University

Institutional National Research Service Award Recipient - April 2013

School of Medicine’s Outstanding Graduate Student - December 2011

Graduate Dean’s Citation - December 2011

American Heart Association Predoctoral Fellowship - July 2008 - June 2010

American Heart Association Basic Cardiovascular Science Travel Award - 2007

Integrated Programs in Biomedical Sciences (IPIBS) Doctoral Fellowship - 2006 - 2008

Abraham D M, Lee T E, Watson L J, Mao L, Chandok G, Wang H G, Frangakis S, Pitt G S, Wolf M J, Rockman H A. A Two Pore Potassium Channel TREK-1 Mediates Cardiac Fibrosis and Diastolic Dysfunction (Submitted Nature)

Dassanayaka S*, Brainard R E*, Watson L J, Long B W, Brittain K R, Demartino A M, Aird A L, Muthusamy S, Hamid T, Prabhu S D, Jones S P. Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy (Submitted Am J Physiol Heart Circ Physiol.)

Pironti G, Stanchan R T, Abraham D, Yu, S, Chen M, Chen W, Hanada K, Mao L, Watson L J, and Rockamn H A. Circulating exosomes induced by pressure overload contain functional Angiotensin II type 1 receptors. Circulation. 2015 Jun 16;131(24):2120-30.

Muthusamy S, De Martino A M, Watson L J, Brittian K R, Zafir A, Dassanayaka S, Hong K U, Jones S P. MicroRNA-539 is upregulated in failing and diabetic hearts, and suppresses O-GlcNAcase expression J Biol Chem. 2014 Oct 24;289(43):29665-76.

Sansbury B E*, DeMartino A M*, Xie Z*, Brooks A C*, Brainard R E, Watson L J, DiFilippis A P, Cummins T D, Harbeson M A, Brittian K R, Prabhu S D, Bhatnagar A, Jones S P, and Hill B G. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail. 2014 Jul;7(4):634-42.

Watson L J, Long B W, DeMartino A M, Brittian K R, Readnower R D, Brainard R E, Cummins T D, Annamalai L, Hill B G, and Jones S P. Cardiomyocyte ogt is Essential for Postnatal Viability. Am J Physiol Heart Circ Physiol. 2014 Jan;306(1):H142-53.

Brainard R E, Watson L J, DeMartino A M, Brittian K R, Readnower R D, Boakye A A, Zhang D, Hoetker J D, Bhatnagar A, Baba S P, Jones S P. High Fat Feeding in Mice Is Insufficient to Induce Cardiac Dysfunction and Does Not Exacerbate Heart Failure. PLoS One. 2013 Dec 18;8(12):e83174

Wang J, Xu J, Wang Q, Brainard R E, Watson L J, Jones S P, and Epstein P N. Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction. PLoS One. 2013;8(1):e53951

Facundo H T*, Brainard R E*, Watson L J, Ngoh G A, Hamid T, Prabhu S D, and Jones S P. O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2122-30.

Wang J, Wang Q, Watson L J, Jones S P, and Epstein P N. Cardiac overexpression of mitochondrial 8-oxoguanine DNA glycosylase 1 protects against cardiac fibrosis following transaortic constriction. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2073-80

Ngoh G A, Watson L J, Facundo H T, and Jones S P. Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes. Amino Acids. 2011 Mar;40(3):895-911

Watson L J, Facundo H T, Ngoh G A, Ameen M, Brainard R E, Lemma K M, Long B W, Prabhu S D, Xuan Y, and Jones S P. O-GlcNAc transferase is indispensable in the failing heart. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17797-802

Ngoh G A, Watson L J, Facundo H T, Dillmann W, and Jones S P. Non-canonical glycosyltransferase modulates post-hypoxic myocyte death and mitochondrial permeability transition. Jol Mol Cell Cardiol. 2008 Aug;45(2):313-25.

Wang Q, Donthi R V, Wang J, Lange A J, Watson L J, Jones S P, and Epstein P N. Cardiac phosphatase-deficient 6-phosphofructokinase-2-kinase/fructose-2,6-bisphosphotase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2889-97.

Greer J J, Kakkar A K, Elrod J W, Watson L J, Jones S P, and Lefer D J. Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure. Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2743-51.

Dassanayaka S, Brainard R E, Watson L J, Long B W, Brittian K R, DeMartino A M, Aird A L, Kilfoil P J, Muthusamy S, Hamid T, Prabhu S D, Jones S P. Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy. FASEB J April 2016 30:1273.2

Abraham D M, Lee T E, Watson L J, Mao L, Chandock G, Wolf M J, Rockman H A. TREK-1 Modulates Fibrosis & Diastolic Dysfunction Through Activation of Stress-Activated Kinases. Circulation. 2014;130:A14688

DeMartino A M, Brainard R E, Watson L, Brittian K R, Readnower R D, Boakye A A, Zhang D, Hoetker J D, Bhatnagar A, Baba S P, and Jones S P. High Fat Feeding in Mice is Insufficient to Induce Cardiac Dysfunction and does not Exacerbate Heart Failure. FASEB J April 2014 28:688.11

DeMartino A M, Watson L, Long B W, Brittian K R, Readnower R D, Brainard R E, Cummins T D, Annamalai L, Hill B G, and Jones S P. Cardiomyocyte Ogt is essential for maintaining cardiac function. FASEB J April 2014 28:1078.1

Muthusamy S, Watson L J, Hong K U, and Jones S P. MicroRNA-539 Upregulation Suppresses O-GlcNAcase in the Failing Heart. Circulation. 2013;128:A18609

Brooks A C, Sansbury B E, Xie Z, Brainard R E, Watson L J, Brittian K R, Prabhu S D, Jones S P, Bhatnagar A, and Hill B G. Metabolic analysis of the early and late hypertrophic heart. Circulation Research. 2011;109:AP137

Watson L J, Jones S P. High fat diet does not exacerbate infarct induced heart failure. FASEB J. March 2011 25:1097.16

Watson L J, Ngoh G A, and Jones S P. Temporal changes in O-GlcNAc signaling during myocardial ischemia reperfusion. Basic Cardiovascular Sciences Scientific Sessions 2010. *In Top 10% of abstracts accepted.

Watson L J, Facundo H T, Ngoh, G A, and Jones S P. O-GlcNAc Transferase deficiency exacerbates metabolic defects in the failing heart. FASEB J. April 2009 23:793.18.

Ngoh G A, Watson L J, and Jones S P. Loss of O-GlcNAc Transferase activity sensitizes cardiac myocytes to post-hypoxic death. FASEB J. April 2008 22:750.10.

Watson L J, Facundo H T, Ngoh G A, Hamid T, Prabhu S D, Xuan Y, and Jones S P. O-GlcNAc Transferase is indispensable in heart failure. Circulation. Oct 2008;118:S_442.

Ngoh G A, Watson L J, and Jones S P. O-GlcNAc Transferase is a pro-survival enzyme in post-hypoxic cardiac myocytes. FASEB J. April 2007 21:726.6.

Ngoh G A, Watson L J, and Jones S P. O-GlcNAcase exacerbates post-hypoxic cardiac myocyte death. FASEB J. 2007 21:958.9.

Watson L J, Ngoh G A, Zhu Y, Campbell A L, Xuan Y, and Jones S P. Paradoxical reduction in glycosylation sensitizes the diabetic heart to mitochondrial permeability transition. Circulation. Oct 2007;116:II_121.

Ngoh G A, Watson L J, Harrison L T, and Jones S P. Degradation of metabolic post-translational modification sensitizes cardiac myocytes to hypoxia. Circulation. Oct 2006;114:II_99.

Josh Watson, Ph.D., was raised in the western reaches of Appalachia on a tobacco and cattle farm in the small town of Liberty, Ky. He received his bachelor’s degree from Western Kentucky University. He served as a laboratory technician for three of his four years and as an independent laboratory instructor for two years. The experiences cemented his desire to both educate and perform research as his career. Following a short stint as laboratory technician at the University of Alabama at Birmingham he began his doctoral training at the University of Louisville. His training at UofL was focused primarily on cardiac physiology and the associated pathologies of heart failure and diabetes. Following completion of his doctorate degree he accepted a postdoctoral position at Duke University where he again focused on cardiovascular biology from a cellular signaling and adrenergic receptor perspective. During his time at Duke, he was reintroduced to the world of education when he was offered several undergraduate anatomy and physiology lectures at nearby community colleges. With his appointment at Duke running out and having a strong desire to be closer to his family he began his search for a position that would allow him to educate, research and serve his home region. He found such an opportunity at KYCOM and the University of Pikeville and now KYCO.

Watson teaches medical physiology for both KYCOM and KYCO as well as spending as much time in the lab as possible. His third research is focused on utilizing Drosophila as a model organism to determine novel therapeutics in diabetes and heart failure. In his free time he enjoys writing short biographies in the third person, cooking for his wife, playing with his three dogs, brewing beer and watching football.

J. Michael Younger, Ph.D.

Associate Professor of Biochemistry

Office: Coal Building 718
Telephone: 606.218.5417
E-mail: MichaelYounger@upike.edu

Medical Biochemistry

Doctor of Philosophy, Cell & Developmental Biology
University of North Carolina – Chapel Hill

Bachelor of Arts, Biology
Lindsey Wilson College

Nuclear Power Machinist & Mechanical Operator – Submarines
Naval Nuclear Power Training Program

Identify functional and structural similarities and differences of cIAP-1 and cIAP-2. These very similar proteins are often, if not always, misregulated in cancer. Determining the redundant and independent roles of these two proteins in both the healthy and diseased state may contribute significantly to our understanding of pathways leading to the inhibition and progression of cancer.

Dr. Younger grew up in North West Indiana (Portage, Ind.) near Chicago. He served in the U.S. Navy aboard the USS Providence SSN 719 Fast Attack Submarine stationed in Groton/New London, Conn., and is a Veteran of Foreign War having served during Desert Storm. He enjoys the outdoors and just about anything that involves wood construction, mechanical repair or troubleshooting, development of renewable energy sources or boating. He is dedicated to spending time with his children and two grandchildren and enjoys life in Pikeville, Ky.

Dana R. Ziegler, Ph.D.

Assistant Professor of Anatomy 

Office: Coal Building 820
Telephone: 606.218.5412
E-mail: DanaZiegler@upike.edu

Gross Anatomy (lab)
Neuroscience (lecture & lab)

Bachelor of Arts, Biology
Wesleyan University

Doctor of Philosophy, Anatomy & Neurobiology
University of Kentucky Medical School

1. Ziegler DR, ME Krcmarik ME, YM Ulrich-Lai, JP Herman, WE Cullinan (2011), Brainstem origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus. J. Comp. Neurol. 520(11):2369-2394

2. YM Ulrich-Lai, KR Jones, DR Ziegler, WE Cullinan, JP Herman. (2011) Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: differential inputs to the anterior versus posterior subregions. J. Comp. Neurol. 519(7):1301-1319.

3. DR Ziegler, WE Cullinan, JP Herman. (2005) Organization and Regulation of Paraventricular Nucleus Glutamate Signaling Systems: NMDA receptors. J. Comp. Neurol., 484(1):43-56

4. DR Ziegler and M Gallagher. (2005) Spatial memory in middle-aged female rats: assessment of estrogen replacement after ovariectomy. Brain Research 1052(2):163-173

5. KA Helm, DR Ziegler, M Gallagher. (2004) Habituation to Stress and Dexamethasone Suppression in Rats with Selective Basal Forebrain Cholinergic Lesions. Hippocampus 14(5):628-635

6. DR Ziegler, WE Cullinan, JP Herman. (2002) Distribution of vesicular glutamate transporter mRNA in rat hypothalamus. J. Comp. Neurol. 448:217-229

7. DR Ziegler, JP Herman. (2000) Local integration of glutamate signaling in the hypothalamic paraventricular region: regulation of glucocorticoid stress responses. Endocrinology 141(12):4801-4804

8. JP Herman, O Eyigor, DR Ziegler, L Jennes. (2000) Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat. J. Comp Neurol. 422:352-362

9. WA Pedersen, C Culmsee, DR Ziegler, JP Herman, MP Mattson. (1999) Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease. J. Mol. Neurosci. 13:159-165

10. DR Ziegler, WA Cass, JP Herman. (1999) Excitatory influence of the locus coeruleus in hypothalamic-pituitary-adrenocortical axis responses to stress.
J Neuroendocrinology 11:361-369

Dr. Ziegler’s core research interest is the neuroanatomical and neurochemical pathways that activate or inhibit the release of stress hormones (glucocorticoids) and how dysfunction in these brain systems play a role in the development and treatment of such mental health disorders as depression and post-traumatic stress disorder (PTSD). Regulation of this neuroendocrine stress response system by the brain is critical not only for catabolic energy mobilization and the physiological defense of homeostasis but also for adaptive behavioral responses and optimal cognitive function during and following stressful events. However, either deficient or excessive glucocorticoid secretion patterns can lead to impaired neuronal cell function and morphology, disrupted neurochemical signaling in the brain and dysfunctional regulation of gene expression because glucocorticoid receptors act as transcription factors in the periphery and brain.

Dr. Ziegler’s research has focused on dissecting the neuroanatomy and functional role of noradrenergic, glutamatergic and GABAergic pathways that encode stressful stimuli and act to activate or inhibit the hypothalamic-pituitary-adrenocortical (HPA) axis via projections that converge on a key site in the brain: the hypothalamic paraventricular nucleus (PVH). This nucleus contains neurons that secrete corticotropin-releasing hormone, which initiates the HPA stress response and ultimately drives glucocorticoid secretion from the adrenal cortex. 

More recently, Dr. Ziegler’s interests have expanded to examine the interactions between anxiety-related brain systems and HPA/stress neurocircuitry. Here at KYCOM, Dr. Ziegler will be primarily dedicated to teaching neuroscience and other anatomy courses. However, through collaborations with other neuroscientists, another research avenue of interest is to investigate the role of individual differences in HPA stress responses in two animal models of PTSD: 1) predator stress and 2) impaired fear conditioning or extinction learning. Collectively, these studies have involved a range of experimental approaches and techniques, including: localized neurotoxic or immunotoxic lesions or neuropharmacological infusions, tract-tracing, immunohistochemistry, in situ hybridization and an array of behavioral tests.

Postdoctoral Trainee Fellowship, National Institute of Mental Health
National Research Service Award (NRSA) Predoctoral Fellowship, National Institute of Mental Health
Predoctoral Trainee Fellowship, National Institute of Aging

1. WE Cullinan, DR Ziegler, JP Herman. (2008) Functional Role of Local GABAergic Influences on the HPA Axis. Brain Structure & Function. 213:63-72

2. DR Ziegler & JP Herman. (2002) Neurocircuitry of Stress Integration: Anatomical Pathways Regulating the Hypothalamo-Pituitary-Adrenocortical Axis of the Rat. Integr. Comp. Biol., Jul 2002; 42: 541 – 551

Dr. Ziegler joined the KYCOM faculty in August 2013. Outside the classroom and lab, he will often be found on the running trails in the area or running, hiking or biking through the great state parks close by, anywhere with live music and at the Jenny Wiley Theatre. Originally from the east coast, his career has taken him through Lexington (graduate school at University of Kentucky) and Cincinnati, then postdoctoral research in Baltimore and Milwaukee, before arriving in Pikeville.


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